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QbD-Based Development of Lurasidone Hydrochloride Solid Lipid Nanoparticles Using a Box–Behnken Design
@qbd-lurasidone-solid-lipid-nanoparticles-box-behnken
M.Pharm
QTPP, risk assessment, 17 Design-Expert runs, a design space and a rat PK study — a full M.Pharm research-work plan
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- Design-Expert (Box–Behnken design, ANOVA, desirability)
- Hot homogenisation + probe sonication
- Zetasizer (DLS size, PDI, zeta potential)
- UV-Visible spectrophotometry / RP-HPLC
- +4
Pharmaceuticsadvanced26 weeksAll India
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Fast-Dissolving Oral Film of Ondansetron for Paediatric Chemotherapy-Induced Nausea: 3² Factorial Optimisation
@ondansetron-fast-dissolving-oral-film-3-2-factorial-paediatric
M.Pharm
Solvent-cast HPMC films, polymer and plasticiser as factors, disintegration, strength and two-minute release as responses, optimised in Design-Expert.
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- Solvent casting (film applicator / glass moulds, hot-air oven)
- Design-Expert (3² full factorial, ANOVA, desirability optimisation)
- UV-visible spectrophotometry (assay, dissolution)
- FTIR and DSC (drug-excipient compatibility)
- +3
Pharmaceuticsadvanced26 weeksAll India
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